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| http://purl.uniprot.org/citations/15911877 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon-gamma (IFN-gamma) is believed to contribute to immune-mediated demyelinating disorders by targeting the myelin-producing oligodendrocyte, a cell known to be highly sensitive to the disruption of protein synthesis and to the perturbation of the secretory pathway. We found that apoptosis induced by IFN-gamma in cultured rat oligodendrocytes was associated with endoplasmic reticulum (ER) stress. ER stress also accompanied oligodendrocyte apoptosis and hypomyelination in transgenic mice that inappropriately expressed IFN-gamma in the central nervous system (CNS). Compared with a wild-type genetic background, the enforced expression of IFN-gamma in mice that were heterozygous for a loss of function mutation in pancreatic ER kinase (PERK) dramatically reduced animal survival, promoted CNS hypomyelination, and enhanced oligodendrocyte loss. PERK encodes an ER stress-inducible kinase that phosphorylates eukaryotic translation initiation factor 2alpha and specifically maintains client protein homeostasis in the stressed ER. Therefore, the hypersensitivity of PERK+/-mice to IFN-gamma implicates ER stress in demyelinating disorders that are induced by CNS inflammation."xsd:string |
| http://purl.uniprot.org/citations/15911877 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200502086"xsd:string |
| http://purl.uniprot.org/citations/15911877 | http://purl.uniprot.org/core/author | "Lin W."xsd:string |
| http://purl.uniprot.org/citations/15911877 | http://purl.uniprot.org/core/author | "Harding H.P."xsd:string |
| http://purl.uniprot.org/citations/15911877 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/15911877 | http://purl.uniprot.org/core/author | "Popko B."xsd:string |
| http://purl.uniprot.org/citations/15911877 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15911877 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15911877 | http://purl.uniprot.org/core/pages | "603-612"xsd:string |
| http://purl.uniprot.org/citations/15911877 | http://purl.uniprot.org/core/title | "Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma."xsd:string |
| http://purl.uniprot.org/citations/15911877 | http://purl.uniprot.org/core/volume | "169"xsd:string |
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