| http://purl.uniprot.org/citations/15916720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15916720 | http://www.w3.org/2000/01/rdf-schema#comment | "Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited an increased reactivity with basophils activated by anti-IgE-mediated cross-linking of the high affinity IgE receptor (FceRI). These include antibodies against CD164 (WS-80160, clone N6B6 and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities that were identified as CD13 (WS-80274, clone A8) and CD107a (WS-80280, clone E63-880). The activation patterns followed either the "CD203c-like" or "CD63-like" activation profile. The CD203c profile is characterized by a rapid and significant upregulation (of CD13, CD164, and CD203c), reaching maximum levels after 5-15 min of stimulation. The Phosphoinositide-3-kinase (PI3K)-specific inhibitor Wortmannin inhibited the upregulation of these markers whereas 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced a rapid and FceRI-independent upregulation within 1-2 min. In the CD63 profile, maximum upregulation (of CD63 and CD107a) was detected only after 20-40 min, and upregulation by TPA reached maximum levels after 60 min. In summary, our data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. Based on time kinetics of upregulation, we hypothesize that molecules of the "CD203c group" and the "CD63 group" are linked to two different mechanisms of basophil activation."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cr.7290301"xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/author | "Nordheim A."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/author | "Valent P."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/author | "Florian S."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/author | "Jakob A."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/author | "Buhring H.J."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/author | "Biedermann T."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/author | "Baumgartner K."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/author | "Hennersdorf F."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/author | "Sonneck K."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/name | "Cell Res"xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/pages | "325-335"xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/title | "Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation."xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15916720 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15916720 |
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| http://purl.uniprot.org/uniprot/#_B4DP96-mappedCitation-15916720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15916720 |