| http://purl.uniprot.org/citations/15919722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15919722 | http://www.w3.org/2000/01/rdf-schema#comment | "Androgen receptor (AR) is important in male sexual differentiation and testicular function. Here, we demonstrate the regulation of AR expression and its transactivation by the basic helix-loop-helix (bHLH) transcription factor Pod-1, the expression of which in postnatal testis reciprocally coincides with the expression of AR. Pod-1 represses the promoter activity of AR, possibly through its E-box. An AR promoter region of 169 bp, which harbors one canonical E-box, is sufficient for the Pod-1-repression and bound by purified Pod-1 proteins. Pod-1 also suppresses the transactivation of AR. Transient transfection analyses of mammalian cells show that Pod-1 represses AR transactivation in a dose-dependent manner. Furthermore, yeast two-hybrid, glutathione-S-transferase-pull-down, and co-immunoprecipitation analyses reveal that Pod-1 directly associates with AR through its N-terminal region and through the DNA binding-hinge domain of AR. Interestingly, Pod-1 recruits histone deacetylase (HDAC)-1 to inhibit both promoter activity and transactivation of AR. Overexpression of HDAC1 further inhibits the Pod-1-mediated repressions and Pod-1 directly interacts with HDAC1. Furthermore, chromatin immunoprecipitation assay reveals that HDAC1 is recruited with Pod-1 to the endogenous AR promoter and the androgen-regulated Pem promoter. Taken together, these results suggest that Pod-1, which controls AR transcription and function, may play an important role in the development and function of the testis."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2004-0400"xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/author | "Lee H.J."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/author | "Choi H.S."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/author | "Hong C.Y."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/author | "Gong E.Y."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/author | "Suh J.H."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/author | "Ko H.M."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/pages | "2245-2257"xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/title | "Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1."xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/15919722 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15919722 |
| http://purl.uniprot.org/citations/15919722 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15919722 |
| http://purl.uniprot.org/uniprot/Q13547#attribution-1F6D59E6E6EA70086AF66B07EAD00725 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15919722 |
| http://purl.uniprot.org/uniprot/O35437#attribution-11A4DF41CFD97F3083D0061DFE52AFAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15919722 |
| http://purl.uniprot.org/uniprot/O35437#attribution-1F6D59E6E6EA70086AF66B07EAD00725 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15919722 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7S0-mappedCitation-15919722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919722 |
| http://purl.uniprot.org/uniprot/#_O35437-mappedCitation-15919722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919722 |
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| http://purl.uniprot.org/uniprot/#_P19091-mappedCitation-15919722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919722 |