| http://purl.uniprot.org/citations/15919756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15919756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15919756 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously cloned and characterized a novel RNA-binding motif-containing coactivator, named coactivator activator (CoAA), as a thyroid hormone receptor-binding protein-interacting protein using a Sos-Ras yeast two-hybrid screening system. A database search revealed that CoAA is identical with synovial sarcoma translocation (SYT)-interacting protein. Thus, we hypothesized that SYT could also function as a coactivator. Subsequently, we isolated a cDNA encoding a larger isoform of SYT, SYT-long (SYT-L), from the brain and liver total RNA using RT-PCR. SYT-L possesses an additional 31 amino acids in its C terminus compared with SYT, suggesting that these two SYT isoforms may be expressed from two mRNAs produced by alternative splicing of a transcript from a single gene. By Northern blot analysis, we found that SYT-L mRNA is expressed in several human embryonic tissues, such as the brain, liver, and kidney. However, we could not detect SYT-L in adult tissues. Glutathione-S-transferase pull-down studies showed that SYT binds to the C-terminus of CoAA, but not to the coactivator modulator. Both isoforms of SYT function as transcriptional coactivators of nuclear hormone receptors in a ligand- and dose-dependent manner in CV-1, COS-1, and JEG-3 cells. However, the pattern of transactivation was different between SYT and SYT-L among these cells. SYT synergistically activates transcription with CoAA. In addition, SYT activates transcription through activator protein-1, suggesting that SYT may function as a general coactivator. These results indicate that SYT activates transcription, possibly through CoAA, to interact with the histone acetyltransferase complex."xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2004-1513"xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2004-1513"xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/author | "Iwasaki T."xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/author | "Iwasaki T."xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/author | "Chin W.W."xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/author | "Chin W.W."xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/author | "Koibuchi N."xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/author | "Koibuchi N."xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/pages | "3892-3899"xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/pages | "3892-3899"xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/title | "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator."xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/title | "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator."xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/15919756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15919756 |
| http://purl.uniprot.org/citations/15919756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15919756 |
| http://purl.uniprot.org/citations/15919756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15919756 |
| http://purl.uniprot.org/citations/15919756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15919756 |