| http://purl.uniprot.org/citations/15919813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15919813 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling molecules. Due to its chromosomal location under a chromosome 20 linkage peak and the metabolic effects of its absence in knockout mice, it is a candidate gene for type 2 diabetes. Recent studies have associated common sequence variants in PTPN1 with type 2 diabetes and diabetes-related phenotypes. We sought to replicate the association of common single nucleotide polymorphisms (SNPs) and haplotypes in PTPN1 with type 2 diabetes, fasting plasma glucose, and insulin sensitivity in a large collection of subjects. We assessed linkage disequilibrium, selected tag SNPs, and typed these markers in 3,347 cases of type 2 diabetes and 3,347 control subjects as well as 1,189 siblings discordant for type 2 diabetes. Despite power estimated at >95% to replicate the previously reported associations, no statistically significant evidence of association was observed between PTPN1 SNPs or common haplotypes with type 2 diabetes or with diabetic phenotypes."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.org/dc/terms/identifier | "doi:10.2337/diabetes.54.6.1884"xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Altshuler D."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Daly M.J."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Sun M."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Burtt N.P."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Florez J.C."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Groop L."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Hirschhorn J.N."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Hudson T.J."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Gaudet D."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Almgren P."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Rastam L."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Tuomi T."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Ardlie K.G."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/author | "Agapakis C.M."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/pages | "1884-1891"xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/title | "Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people."xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/15919813 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15919813 |
| http://purl.uniprot.org/citations/15919813 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15919813 |
| http://purl.uniprot.org/uniprot/#_A8K3M3-mappedCitation-15919813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919813 |