| http://purl.uniprot.org/citations/15919943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15919943 | http://www.w3.org/2000/01/rdf-schema#comment | "TRIM5 is a determinant of species-specific differences in susceptibility to infection by retroviruses bearing particular capsids. Human immunodeficiency virus type 1 (HIV-1) infection is blocked by the alpha isoform of macaque TRIM5 (TRIM5alpha(rh)) or by the product of the owl monkey TRIM5-cyclophilin A gene fusion (TRIMCyp). Human TRIM5alpha potently restricts specific strains of murine leukemia virus (N-MLV) but has only a modest effect on HIV-1. The amino termini of TRIM5 orthologues are highly conserved and possess a coiled-coil domain that promotes homomultimerization. Here we show that heterologous expression of TRIM5alpha(rh) or TRIMCyp in human cells interferes with the anti-N-MLV activity of endogenous human TRIM5alpha (TRIM5alpha(hu)). Deletion of the cyclophilin domain from TRIMCyp has no effect on heteromultimerization or colocalization with TRIM5alpha(hu) but prevents interference with anti-N-MLV activity. These data demonstrate that TRIM5 orthologues form heteromultimers and indicate that C-terminal extensions alter virus recognition by multimers of these proteins."xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.12.7883-7888.2005"xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://purl.uniprot.org/core/author | "Sebastian S."xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://purl.uniprot.org/core/author | "Luban J."xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://purl.uniprot.org/core/author | "Berthoux L."xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://purl.uniprot.org/core/author | "Sayah D.M."xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15919943 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://purl.uniprot.org/core/pages | "7883-7888"xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://purl.uniprot.org/core/title | "Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues."xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/15919943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15919943 |
| http://purl.uniprot.org/citations/15919943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15919943 |
| http://purl.uniprot.org/uniprot/Q2Y080#attribution-2F9522542B0B8A1EF68846882289EB29 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15919943 |
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| http://purl.uniprot.org/uniprot/#_B1Q3L0-mappedCitation-15919943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919943 |
| http://purl.uniprot.org/uniprot/#_D8L1Z7-mappedCitation-15919943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919943 |
| http://purl.uniprot.org/uniprot/#_D8L1Z8-mappedCitation-15919943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919943 |
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| http://purl.uniprot.org/uniprot/#_D8L202-mappedCitation-15919943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919943 |
| http://purl.uniprot.org/uniprot/#_D8L203-mappedCitation-15919943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919943 |
| http://purl.uniprot.org/uniprot/#_Q05CU3-mappedCitation-15919943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15919943 |