| http://purl.uniprot.org/citations/15920156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15920156 | http://www.w3.org/2000/01/rdf-schema#comment | "We have shown previously that the hypomineralization defects of the calvarium and vertebrae of tissue nonspecific alkaline phosphatase (TNAP)-deficient (Akp2-/-) hypophosphatasia mice are rescued by simultaneous deletion of the Enpp1 gene, which encodes nucleotide pyrophosphatase phosphodiesterase 1 (NPP1). Conversely, the hyperossification in the vertebral apophyses typical of Enpp1-/-mice is corrected in [Akp2-/-; Enpp1-/-] double-knockout mice. Here we have examined the appendicular skeletons of Akp2-/-, Enpp1-/-, and [Akp2-/-; Enpp1-/-] mice to ascertain the degree of rescue afforded at these skeletal sites. Alizarin red and Alcian blue whole mount analysis of the skeletons from wild-type, Akp2-/-, and [Akp2-/-; Enpp1-/-] mice revealed that although calvarium and vertebrae of double-knockout mice were normalized with respect to mineral deposition, the femur and tibia were not. Using several different methodologies, we found reduced mineralization not only in Akp2-/-but also in Enpp1-/- and [Akp2-/-; Enpp1-/-] femurs and tibias. Analysis of calvarial- and bone marrow-derived osteoblasts for mineralized nodule formation in vitro showed increased mineral deposition by Enpp1-/-calvarial osteoblasts but decreased mineral deposition by Enpp1-/-long bone marrow-derived osteoblasts in comparison to wild-type cells. Thus, the osteomalacia of Akp2-/-mice and the hypomineralized phenotype of the long bones of Enpp1-/-mice are not rescued by simultaneous deletion of TNAP and NPP1 functions."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)62481-9"xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Johnson K."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Bi X."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Garimella R."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Terkeltaub R."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Millan J.L."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Anderson H.C."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Harmey D."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Camacho N.P."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Sipe J.B."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/author | "Tague S."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/pages | "1711-1720"xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/title | "Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/15920156 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15920156 |
| http://purl.uniprot.org/citations/15920156 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15920156 |
| http://purl.uniprot.org/uniprot/#_E9Q7P8-mappedCitation-15920156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15920156 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1Q7-mappedCitation-15920156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15920156 |
| http://purl.uniprot.org/uniprot/#_B7XGA6-mappedCitation-15920156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15920156 |
| http://purl.uniprot.org/uniprot/#_B1AXF5-mappedCitation-15920156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15920156 |
| http://purl.uniprot.org/uniprot/#_B1AXF6-mappedCitation-15920156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15920156 |