| http://purl.uniprot.org/citations/15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15922711 | http://www.w3.org/2000/01/rdf-schema#comment | "B-cell receptor (BCR) ligation induces proliferation and survival in mature B-cells but conversely, can lead to apoptosis in immature B-cells. We have previously shown that c-Rel, a member of the NF-kappaB transcription factor family, is essential for mature B-cell survival and proliferation via regulation of the anti-apoptotic molecule Bcl-X and cell cycle genes E2F3a and cyclin E. Here, we report that c-Rel-deficient mature B-cells are rendered sensitive to BCR-induced growth arrest and apoptosis in a manner that strongly resembles the phenotypic response of immature B-cells to BCR signaling. We further demonstrate that BCR-stimulated immature B-cells are defective in NF-kappaB activation, but that introduction of two downstream c-Rel target genes, Bcl-X and cyclin E, can restore survival and proliferation to these cells. Our studies therefore suggest that specific blockade of NF-kappaB activation may be responsible for the growth arrest and apoptosis of BCR-activated immature B-cells."xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2005.01.006"xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/author | "Cheng S."xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/author | "Feng B."xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/author | "King L.B."xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/author | "Monroe J.G."xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/author | "Liou H.C."xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/author | "Hsia C.Y."xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/pages | "9-20"xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/title | "NF-kappaB inducible genes BCL-X and cyclin E promote immature B-cell proliferation and survival."xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://purl.uniprot.org/core/volume | "232"xsd:string |
| http://purl.uniprot.org/citations/15922711 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15922711 |
| http://purl.uniprot.org/citations/15922711 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15922711 |
| http://purl.uniprot.org/uniprot/#_P15307-mappedCitation-15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922711 |
| http://purl.uniprot.org/uniprot/#_A2AHX7-mappedCitation-15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922711 |
| http://purl.uniprot.org/uniprot/#_A2AHX8-mappedCitation-15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922711 |
| http://purl.uniprot.org/uniprot/#_A2AHX9-mappedCitation-15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922711 |
| http://purl.uniprot.org/uniprot/#_A4QPD3-mappedCitation-15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922711 |
| http://purl.uniprot.org/uniprot/#_O35843-mappedCitation-15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922711 |
| http://purl.uniprot.org/uniprot/#_Q64373-mappedCitation-15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922711 |
| http://purl.uniprot.org/uniprot/#_Q3T9W4-mappedCitation-15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922711 |
| http://purl.uniprot.org/uniprot/#_Q5HZH3-mappedCitation-15922711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922711 |