| http://purl.uniprot.org/citations/15922712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15922712 | http://www.w3.org/2000/01/rdf-schema#comment | "Engagement of the T cell receptor (TCR) by antigen or anti-CD3 antibody results in a cycle of internalization and re-expression of the CD3zeta. Following internalization, CD3zeta is degraded and replaced by newly synthesized CD3zeta on the cell surface. Here, we provide evidence that availability of the amino acid L-arginine modulates the cycle of internalization and re-expression of CD3zeta and cause T cell dysfunction. T cells stimulated and cultured in presence of L-arginine, undergo the normal cycle of internalization and re-expression of CD3zeta. In contrast, T cells stimulated and cultured in absence of L-arginine, present a sustained down-regulation of CD3zeta preventing the normal expression of the TCR, exhibit a decreased proliferation, and a significantly diminished production of IFNgamma, IL5, and IL10, but not IL2. The replenishment of L-arginine recovers the expression of CD3zeta. The decreased expression of CD3zeta is not caused by a decreased CD3zeta mRNA, an increased CD3zeta degradation or T cell apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2005.01.004"xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/author | "Ochoa A.C."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/author | "Ochoa J.B."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/author | "Rodriguez P.C."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/author | "Zabaleta J."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/author | "Zea A.H."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/author | "Park H.J."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/author | "Culotta K.S."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/author | "DeSalvo J."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/author | "Hernandez C.P."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/pages | "21-31"xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/title | "L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://purl.uniprot.org/core/volume | "232"xsd:string |
| http://purl.uniprot.org/citations/15922712 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15922712 |
| http://purl.uniprot.org/citations/15922712 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15922712 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TPP4-mappedCitation-15922712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922712 |
| http://purl.uniprot.org/uniprot/#_A0A5A4N2X8-mappedCitation-15922712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922712 |
| http://purl.uniprot.org/uniprot/#_A0A5A4N5K5-mappedCitation-15922712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922712 |
| http://purl.uniprot.org/uniprot/#_A9Y844-mappedCitation-15922712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922712 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TQM0-mappedCitation-15922712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922712 |
| http://purl.uniprot.org/uniprot/#_B2LYR2-mappedCitation-15922712 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15922712 |