| http://purl.uniprot.org/citations/15923164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15923164 | http://www.w3.org/2000/01/rdf-schema#comment | "We analyzed survivin as a marker of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HR-HPV) and a predictor of HPV clearance and disease outcome in cervical cancer in 302 samples (squamous cell carcinomas [SCCs], 150; CIN lesions, 152) by immunohistochemical staining with survivin antibody and HPV testing using polymerase chain reaction. HR-HPV types were associated closely with CIN and SCC. There was a significant linear relationship between grade and intensity of survivin expression (P = .0001). Survivin overexpression also was associated strongly with HR-HPV type (P = .0001). Multivariate regression analysis revealed survivin and p16(INK4a) as equally strong independent predictors of HR-HPV. Deregulated survivin expression did not predict clearance or persistence of HR-HPV after treatment of CIN or survival in cervical cancer in univariate (P = .417) or multivariate analysis. After adjustment for HR-HPV, stage, age, and tumor grade in the Cox regression model, only stage (P = .0001) and age (P = .0001) remained independent prognostic predictors. Survivin seems to be an early marker of cervical carcinogenesis. Up-regulated survivin expression was an independent predictor of HR-HPV in cervical lesions, most plausibly explained by its normal transcriptional repression by wild-type p53 being eliminated by HR-HPV E6 oncoprotein."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.org/dc/terms/identifier | "doi:10.1309/l8bwf431wu9ac8fj"xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Giorgi C."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Ciotti M."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Favalli C."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Accardi L."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Mariani L."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Costa S."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Benedetto A."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Syrjanen K."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Santini D."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Syrjanen S."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Bonifacio D."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Di Bonito L."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Di Bonito P."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Branca M."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Casolati E.A."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Paba P."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/author | "Zanconati F."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/name | "Am J Clin Pathol"xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/pages | "113-121"xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/title | "Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer."xsd:string |
| http://purl.uniprot.org/citations/15923164 | http://purl.uniprot.org/core/volume | "124"xsd:string |