| http://purl.uniprot.org/citations/15924437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15924437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15924437 | http://www.w3.org/2000/01/rdf-schema#comment | "Most of the >50,000 different pharmacologically active peptides in Conus venoms belong to a small number of gene superfamilies. In this work, the M-conotoxin superfamily is defined using both biochemical and molecular criteria. Novel excitatory peptides purified from the venoms of the molluscivorous species Conus textile and Conus marmoreus all have a characteristic pattern of Cys residues previously found in the mu-, kappaM-, and psi-conotoxins (CC-C-C-CC). The new peptides are smaller (12-19 amino acids) than the mu-, kappaM-, and psi-conotoxins (22-24 amino acids). One peptide, mr3a, was chemically synthesized in a biologically active form. Analysis of the disulfide bridges of a natural peptide tx3c from C. textile and synthetic peptide mr3a from C. marmoreus showed a novel pattern of disulfide connectivity, different from that previously established for the mu- and psi-conotoxins. Thus, these peptides belong to a new group of structurally and pharmacologically distinct conotoxins that are particularly prominent in the venoms of mollusc-hunting Conus species. Analysis of cDNA clones encoding the novel peptides as well as those encoding mu-, kappaM-, and psi-conotoxins revealed highly conserved amino acid residues in the precursor sequences; this conservation in both amino acid sequence and in the Cys pattern defines a gene superfamily, designated the M-conotoxin superfamily. The peptides characterized can be provisionally assigned to four distinct groups within the M-superfamily based on sequence similarity within and divergence between each group. A notable feature of the superfamily is that two distinct structural frameworks have been generated by changing the disulfide connectivity on an otherwise conserved Cys pattern."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi047541b"xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi047541b"xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Walker C."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Walker C."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "McIntosh J.M."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "McIntosh J.M."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Hillyard D.R."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Hillyard D.R."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Cruz L.J."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Cruz L.J."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Watkins M."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Watkins M."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Jimenez E.C."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Jimenez E.C."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Gray W.R."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Gray W.R."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Jacobsen R.B."xsd:string |
| http://purl.uniprot.org/citations/15924437 | http://purl.uniprot.org/core/author | "Jacobsen R.B."xsd:string |