| http://purl.uniprot.org/citations/15925437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15925437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15925437 | http://www.w3.org/2000/01/rdf-schema#comment | "6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB) is a bifunctional enzyme, which is responsible for maintaining the cellular level of fructose-2,6-bisphosphate, a powerful allosteric activator of glycolysis. We describe herein the overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 (PFKFB-4) isozyme in the human breast and colon malignant tumors as compared to corresponding non-malignant tissue counterparts. We have shown also that breast malignant cell line MCF7 constitutively express PFKFB-4 mRNA and that the expression of this gene is highly induced by hypoxia. Overexpression of PFKFB-4 transcript levels in breast and colon malignant tumors correlates with enhanced expression of PFKFB-3, hypoxia-inducible factor (HIF)-1alpha and known HIF-1 dependent genes glucose transporter 1 (Glut1) and vascular endothelial growth factor (VEGF). Thus, our data clearly demonstrates overexpression of PFKFB-4 mRNA and protein in the breast and colon malignant tumors."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biochi.2005.04.007"xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biochi.2005.04.007"xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Esumi H."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Esumi H."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Ogura T."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Ogura T."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Ochiai A."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Ochiai A."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Caro J."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Caro J."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Minchenko D.O."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Minchenko D.O."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Minchenko O.H."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Minchenko O.H."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Opentanova I.L."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Opentanova I.L."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Komisarenko S.V."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/author | "Komisarenko S.V."xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/name | "Biochimie"xsd:string |
| http://purl.uniprot.org/citations/15925437 | http://purl.uniprot.org/core/name | "Biochimie"xsd:string |