| http://purl.uniprot.org/citations/15930126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15930126 | http://www.w3.org/2000/01/rdf-schema#comment | "A-kinase-anchoring protein (AKAP) 79/150 organizes a scaffold of cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and protein phosphatase 2B/calcineurin that regulates phosphorylation pathways underlying neuronal long-term potentiation and long-term depression (LTD) synaptic plasticity. AKAP79/150 postsynaptic targeting requires three N-terminal basic domains that bind F-actin and acidic phospholipids. Here, we report a novel interaction of these domains with cadherin adhesion molecules that are linked to actin through beta-catenin (beta-cat) at neuronal synapses and epithelial adherens junctions. Mapping the AKAP binding site in cadherins identified overlap with beta-cat binding; however, no competition between AKAP and beta-cat binding to cadherins was detected in vitro. Accordingly, AKAP79/150 exhibited polarized localization with beta-cat and cadherins in epithelial cell lateral membranes, and beta-cat was present in AKAP-cadherin complexes isolated from epithelial cells, cultured neurons, and rat brain synaptic membranes. Inhibition of epithelial cell cadherin adhesion and actin polymerization redistributed intact AKAP-cadherin complexes from lateral membranes to intracellular compartments. In contrast, stimulation of neuronal pathways implicated in LTD that depolymerize postsynaptic F-actin disrupted AKAP-cadherin interactions and resulted in loss of the AKAP, but not cadherins, from synapses. This neuronal regulation of AKAP79/150 targeting to cadherins may be important in functional and structural synaptic modifications underlying plasticity."xsd:string |
| http://purl.uniprot.org/citations/15930126 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-02-0134"xsd:string |
| http://purl.uniprot.org/citations/15930126 | http://purl.uniprot.org/core/author | "Scott J.D."xsd:string |
| http://purl.uniprot.org/citations/15930126 | http://purl.uniprot.org/core/author | "Dell'Acqua M.L."xsd:string |
| http://purl.uniprot.org/citations/15930126 | http://purl.uniprot.org/core/author | "Gorski J.A."xsd:string |
| http://purl.uniprot.org/citations/15930126 | http://purl.uniprot.org/core/author | "Gomez L.L."xsd:string |
| http://purl.uniprot.org/citations/15930126 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15930126 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/15930126 | http://purl.uniprot.org/core/pages | "3574-3590"xsd:string |
| http://purl.uniprot.org/citations/15930126 | http://purl.uniprot.org/core/title | "Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/15930126 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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