http://purl.uniprot.org/citations/15932944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15932944 | http://www.w3.org/2000/01/rdf-schema#comment | "The survival of CD8+/CD44(hi) memory phenotype T cells depends on an IL-15 activity on nonlymphoid cells. Here, we report that IL-15 and its receptor were induced on dendritic cells (DCs) by a combination of IFN-gamma and NF-kappaB relA inducers. IL-15 conferred in an autocrine loop resistance to apoptosis that accompanied the maturation process in DCs in vitro. As an apparent result in vivo, mice deficient in IL-15 or its receptor harbor few DCs. Injecting DCs into IL-15-/-mice was associated with the appearance of CD8+/CD44(hi) T cells that depended on IL-15 expression but also correlated with the longevity of the DCs. These findings support the hypothesis that DCs mediate the effect of IL-15 on CD8+/CD44(hi) memory phenotype T cells."xsd:string |
http://purl.uniprot.org/citations/15932944 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0503360102"xsd:string |
http://purl.uniprot.org/citations/15932944 | http://purl.uniprot.org/core/author | "Waldmann T.A."xsd:string |
http://purl.uniprot.org/citations/15932944 | http://purl.uniprot.org/core/author | "Muller J.R."xsd:string |
http://purl.uniprot.org/citations/15932944 | http://purl.uniprot.org/core/author | "Dubois S.P."xsd:string |
http://purl.uniprot.org/citations/15932944 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/15932944 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
http://purl.uniprot.org/citations/15932944 | http://purl.uniprot.org/core/pages | "8662-8667"xsd:string |
http://purl.uniprot.org/citations/15932944 | http://purl.uniprot.org/core/title | "Survival adjustment of mature dendritic cells by IL-15."xsd:string |
http://purl.uniprot.org/citations/15932944 | http://purl.uniprot.org/core/volume | "102"xsd:string |
http://purl.uniprot.org/citations/15932944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15932944 |
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