| http://purl.uniprot.org/citations/15935055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15935055 | http://www.w3.org/2000/01/rdf-schema#comment | "Munc18-1, a member of the Sec1/Munc18 (SM) protein family, is essential for synaptic vesicle exocytosis. Munc18-1 binds tightly to the SNARE protein syntaxin 1, but the physiological significance and functional role of this interaction remain unclear. Here we show that syntaxin 1 levels are reduced by 70% in munc18-1 knockout mice. Pulse-chase analysis in transfected HEK293 cells revealed that Munc18-1 directly promotes the stability of syntaxin 1, consistent with a chaperone function. However, the residual syntaxin 1 in munc18-1 knockout mice is still correctly targeted to synapses and efficiently forms SDS-resistant SNARE complexes, demonstrating that Munc18-1 is not required for syntaxin 1 function as such. These data demonstrate that the Munc18-1 interaction with syntaxin 1 is physiologically important, but does not represent a classical chaperone-substrate relationship. Instead, the presence of SNARE complexes in the absence of membrane fusion in munc18-1 knockout mice indicates that Munc18-1 either controls the spatially correct assembly of core complexes for SNARE-dependent fusion, or acts as a direct component of the fusion machinery itself."xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2005.03128.x"xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/author | "Zalm R."xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/author | "Toonen R.F."xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/author | "Verhage M."xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/author | "de Vries K.J."xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/pages | "1393-1400"xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/title | "Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation."xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/15935055 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15935055 |
| http://purl.uniprot.org/citations/15935055 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15935055 |
| http://purl.uniprot.org/uniprot/O88737#attribution-BE26B7672C2C77DE222B393D5F5C59E6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15935055 |
| http://purl.uniprot.org/uniprot/O35526#attribution-BE26B7672C2C77DE222B393D5F5C59E6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15935055 |
| http://purl.uniprot.org/uniprot/P61765#attribution-BE26B7672C2C77DE222B393D5F5C59E6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15935055 |
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| http://purl.uniprot.org/uniprot/#_A0A0U1RNM8-mappedCitation-15935055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15935055 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNT8-mappedCitation-15935055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15935055 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RMH1-mappedCitation-15935055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15935055 |
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| http://purl.uniprot.org/uniprot/#_D3YZ51-mappedCitation-15935055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15935055 |