| http://purl.uniprot.org/citations/15935327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15935327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15935327 | http://www.w3.org/2000/01/rdf-schema#comment | "Down syndrome critical region 1 (DSCR1) is recognized as an endogenous calcineurin inhibitor. DSCR1 is induced in endothelial cells and may play an important role in inflammation and angiogenesis. To address a novel function of DSCR1, we searched interacting partners of DSCR1. We performed pull-down analysis using DSCR1 as a bait and identified Raf-1 as a binding partner. The association of Raf-1 was confirmed by co-immunoprecipitation in GM7373 cells expressing green fluorescence protein tagged DSCR1. We determined two Raf-1 binding regions in DSCR1; one in the N-terminus and the other in the C-terminus regions. We further demonstrated that calpain cleaved DSCR1 and generated fragments with different binding affinity to Raf-1 or calcineurin. These results constitute the first demonstration of Raf-1 as a binding partner of DSCR1, and suggest a novel role of DSCR1."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2005.05.002"xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2005.05.002"xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/author | "Kim S.Y."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/author | "Kim S.Y."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/author | "Cho Y.J."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/author | "Cho Y.J."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/name | "Arch. Biochem. Biophys."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/name | "Arch. Biochem. Biophys."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/pages | "121-128"xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/pages | "121-128"xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/title | "Raf-1 is a binding partner of DSCR1."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/title | "Raf-1 is a binding partner of DSCR1."xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/volume | "439"xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://purl.uniprot.org/core/volume | "439"xsd:string |
| http://purl.uniprot.org/citations/15935327 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15935327 |
| http://purl.uniprot.org/citations/15935327 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15935327 |