| http://purl.uniprot.org/citations/15936277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15936277 | http://www.w3.org/2000/01/rdf-schema#comment | "E2F transcription factors play a pivotal role in the regulation of cellular proliferation and can be subdivided into activating and repressing family members [1]. Like other E2Fs, E2F6 binds to E2F consensus sites, but in contrast to E2F1-5, it lacks an Rb binding domain and functions as an Rb-independent transcriptional repressor [2, 3, 4 and 5]. Instead, E2F6 has been shown to complex with Polycomb (PcG) group proteins [6 and 7], which have a well-established role in gene silencing. Here, we show that E2F6 plays an unexpected and essential role in the tissue specificity of gene expression. E2F6-deficient mice ubiquitously express the alpha-tubulin 3 and 7 genes, which are expressed strictly testis-specifically in control mice. Like an additional E2F6 target gene, Tex12, that we identified, tubulin 3 and 7 are normally expressed in male germ cells only. The promoters of the alpha-tubulin and Tex12 genes share a perfectly conserved E2F site, which E2F6 binds to. Mechanistically, E2F6-mediated repression involves CpG hypermethylation locking target promoters in an inactive state. Thus, E2F6 is essential for the long-term somatic silencing of certain male-germ-cell-specific genes, but it is dispensable for cell-cycle regulation."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2005.04.060"xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Hoffmann B."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Hagemeier C."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Truss M."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Birchmeier C."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Strehle M."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Scholz A."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Morkel M."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Pohlers M."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Kuban R.J."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/author | "Frede U."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/pages | "1051-1057"xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/title | "A role for E2F6 in the restriction of male-germ-cell-specific gene expression."xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15936277 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15936277 |
| http://purl.uniprot.org/citations/15936277 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15936277 |
| http://purl.uniprot.org/uniprot/#_E9Q0S7-mappedCitation-15936277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936277 |
| http://purl.uniprot.org/uniprot/#_E9Q113-mappedCitation-15936277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936277 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VJU3-mappedCitation-15936277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936277 |
| http://purl.uniprot.org/uniprot/#_A0A979HLR9-mappedCitation-15936277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936277 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VP85-mappedCitation-15936277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936277 |