| http://purl.uniprot.org/citations/15936846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15936846 | http://www.w3.org/2000/01/rdf-schema#comment | "Although it was observed that inhibition of the antiapoptotic protein survivin expression in lung cancer cells induces apoptosis, the expression and role of survivin variants (survivin-2B and survivin-DeltaEx3) in lung cancer have not yet been characterized. We analyzed 24 non-small-cell lung cancer (NSCLC) samples by semi-quantitative RT-PCR. Surprisingly, our results revealed that high-level expression of survivin-2B is significantly associated with the patient category of "no relapse and alive" (p-value<0.0001). In contrast, high-level expression of survivin-DeltaEx3 is highly associated with the patient category of "relapse and dead" (p-value<0.0001). Consistent with this observation, exogenous expression of survivin-2B in A549 lung cancer cells inhibited cell growth, disrupted the mitochondria potential, and induced apoptotic cell death, while expression of survivin-DeltaEx3 protected the mitochondria potential and facilitated cell survival. These findings provide evidence that survivin-2B and survivin-DeltaEx3 play opposite roles in disease relapse and NSCLC cell survival, which is likely through the differential modulation of mitochondrial potential. Thus, controlling the differential expression of survivin-2B and survivin-DeltaEx3 may represent novel approaches for cancer therapeutics in NSCLC."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.lungcan.2005.03.037"xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Tan D."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Ling X."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Younis T."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Bundy B.N."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Ramnath N."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/author | "Slocum H.K."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/name | "Lung Cancer"xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/pages | "353-361"xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/title | "Differential expression of survivin-2B and survivin-DeltaEx3 is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC)."xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/15936846 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15936846 |
| http://purl.uniprot.org/citations/15936846 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15936846 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1S3-mappedCitation-15936846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936846 |
| http://purl.uniprot.org/uniprot/#_A0A7L8XZM3-mappedCitation-15936846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936846 |
| http://purl.uniprot.org/uniprot/#_A3E0Z5-mappedCitation-15936846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936846 |
| http://purl.uniprot.org/uniprot/#_A3E0Z6-mappedCitation-15936846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936846 |
| http://purl.uniprot.org/uniprot/#_A3E0Z7-mappedCitation-15936846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15936846 |