| http://purl.uniprot.org/citations/15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15937485 | http://www.w3.org/2000/01/rdf-schema#comment | "Targeted diversification of immunoglobulin variable regions is induced by activation-induced deaminase and may occur by either somatic hypermutation or gene conversion. MRE11-RAD50-NBS1 (MRN) is a ubiquitous and conserved nuclease complex critical for DNA break repair and is essential in class-switch recombination. Here we show that ectopic expression of NBS1, the regulatory subunit of MRN, accelerated hypermutation in the human B cell line Ramos and accelerated gene conversion in the chicken B cell line DT40. In both cases, accelerated diversification depended on MRN complex formation. These data suggest that MRN promotes DNA cleavage and/or mutagenic repair of lesions initiated by activation-induced deaminase, acting in the shared pathway of immunoglobulin gene diversification."xsd:string |
| http://purl.uniprot.org/citations/15937485 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1215"xsd:string |
| http://purl.uniprot.org/citations/15937485 | http://purl.uniprot.org/core/author | "Maizels N."xsd:string |
| http://purl.uniprot.org/citations/15937485 | http://purl.uniprot.org/core/author | "Yabuki M."xsd:string |
| http://purl.uniprot.org/citations/15937485 | http://purl.uniprot.org/core/author | "Fujii M.M."xsd:string |
| http://purl.uniprot.org/citations/15937485 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15937485 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/15937485 | http://purl.uniprot.org/core/pages | "730-736"xsd:string |
| http://purl.uniprot.org/citations/15937485 | http://purl.uniprot.org/core/title | "The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions."xsd:string |
| http://purl.uniprot.org/citations/15937485 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/15937485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15937485 |
| http://purl.uniprot.org/citations/15937485 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15937485 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z438-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG07-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_A8K1D3-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_A6H8Y5-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_A0PJ71-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_F8W7U8-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_P49959-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_G9HTF8-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_L8E9C6-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_O60934-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_Q05D78-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |
| http://purl.uniprot.org/uniprot/#_V9PAF3-mappedCitation-15937485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937485 |