http://purl.uniprot.org/citations/15937486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15937486 | http://www.w3.org/2000/01/rdf-schema#comment | "One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection."xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1212"xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/author | "van Lier R.A."xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/author | "Vargas D."xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/author | "Manjunath N."xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/author | "Laouar A."xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/author | "Haridas V."xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/author | "Chaplin D."xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/author | "Zhinan X."xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/pages | "698-706"xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/title | "CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa."xsd:string |
http://purl.uniprot.org/citations/15937486 | http://purl.uniprot.org/core/volume | "6"xsd:string |
http://purl.uniprot.org/citations/15937486 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15937486 |
http://purl.uniprot.org/citations/15937486 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15937486 |
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http://purl.uniprot.org/uniprot/#_Q3TR87-mappedCitation-15937486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15937486 |