| http://purl.uniprot.org/citations/15939795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15939795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15939795 | http://www.w3.org/2000/01/rdf-schema#comment | "Pre-B cells undergo apoptosis unless they are rescued by pre-B cell receptor-dependent survival signals. We previously showed that the BCR-ABL1 kinase that is expressed in pre-B lymphoblastic leukemia bypasses selection for pre-B cell receptor-dependent survival signals. Investigating possible interference of BCR-ABL1 with pre-B cell receptor signaling, we found that neither SYK nor SLP65 can be phosphorylated in response to pre-B cell receptor engagement. Instead, Bruton's tyrosine kinase (BTK) is constitutively phosphorylated by BCR-ABL1. Activated BTK is essential for survival signals that otherwise would arise from the pre-B cell receptor, including activation of PLCgamma1, autonomous Ca2+ signaling, STAT5-phosphorylation, and up-regulation of BCLX(L). Inhibition of BTK activity specifically induces apoptosis in BCR-ABL1+ leukemia cells to a similar extent as inhibition of BCR-ABL1 kinase activity itself. However, BCR-ABL1 cannot directly bind to full-length BTK. Instead, BCR-ABL1 induces the expression of a truncated splice variant of BTK that acts as a linker between the two kinases. As opposed to full-length BTK, truncated BTK lacks kinase activity yet can bind to BCR-ABL1 through its SRC-homology domain 3. Acting as a linker, truncated BTK enables BCR-ABL1-dependent activation of full-length BTK, which initiates downstream survival signals and mimics a constitutively active pre-B cell receptor."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20042101"xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20042101"xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Klein F."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Klein F."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Rowley J.D."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Rowley J.D."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Herzog S."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Herzog S."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Hofmann W.K."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Hofmann W.K."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Feldhahn N."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Feldhahn N."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Jumaa H."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Jumaa H."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Muschen M."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Muschen M."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Sprangers M."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Sprangers M."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Mooster J.L."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Mooster J.L."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Bekhite M.M."xsd:string |
| http://purl.uniprot.org/citations/15939795 | http://purl.uniprot.org/core/author | "Bekhite M.M."xsd:string |