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http://purl.uniprot.org/citations/15940053http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15940053http://www.w3.org/2000/01/rdf-schema#comment"

Background

The current study attempted to evaluate the association between IL-10 promoter gene polymorphism and transplant outcomes including the occurrence of chronic graft-versus-host disease (GVHD) and its clinical course during systemic immunosuppressive treatment (IST) among 60 recipients of cytokine-mobilized peripheral blood stem cell (PBSC) from HLA-matched sibling donors.

Methods

We analyzed 3 single-nucleotide polymorphisms in proximal region of IL-10 promoter gene (-1082/-819/-592).

Results

In the current study, only two haplotypes (1082*A/819*T/592*A [ATA] and 1082*A/819*C/592*C [ACC]) were found. An increased occurrence of chronic GVHD was noted dependent on the IL-10 haplotypes (43% vs. 68% vs. 96% in ACC/ACC vs. ATA/ACC vs. ATA/ATA haplotype, P=0.003). In a logistic regression based on multinomial model, ATA/ATA homozygote had 7-fold increasing risk of the development of chronic GVHD compared with ACC/ACC homozygote. The incidence of chronic GVHD at 1 year was 46%+/-20%, 64%+/-10%, and 82%+/-5% in ACC/ACC, ATA/ACC and ATA/ATA group, respectively (P=0.0266). Plus, the duration of systemic IST was significantly shorter in recipients without ATA-haplotype comparing with those with ATA haplotype (339 days vs. 1,146 days, P=0.0091).

Conclusion

IL-10 promoter gene polymorphism was found to be apparently associated with chronic GVHD after allogeneic peripheral blood stem cell transplantation from HLA-matched sibling donors."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.org/dc/terms/identifier"doi:10.1097/01.tp.0000159792.04757.d4"xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/author"Kim D.H."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/author"Lee K.B."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/author"Kim J.G."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/author"Lee N.Y."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/author"Baek J.H."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/author"Suh J.S."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/author"Shin I.H."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/author"Sohn S.K."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/name"Transplantation"xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/pages"1615-1622"xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/title"IL-10 promoter gene polymorphism associated with the occurrence of chronic GVHD and its clinical course during systemic immunosuppressive treatment for chronic GVHD after allogeneic peripheral blood stem cell transplantation."xsd:string
http://purl.uniprot.org/citations/15940053http://purl.uniprot.org/core/volume"79"xsd:string
http://purl.uniprot.org/citations/15940053http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15940053
http://purl.uniprot.org/citations/15940053http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15940053
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http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-15940053http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15940053
http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-15940053http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15940053
http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-15940053http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15940053
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