| http://purl.uniprot.org/citations/15947087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15947087 | http://www.w3.org/2000/01/rdf-schema#comment | "The Krüppel-like factors (KLFs) are a family of C2/H2 zinc finger DNA-binding proteins that are important in controlling developmental programs. Erythroid Krüppel-like factor (EKLF or KLF1) positively regulates the beta-globin gene in definitive erythroid cells. KLF2 (LKLF) is closely related to EKLF and is expressed in erythroid cells. KLF2-/-mice die between embryonic day 12.5 (E12.5) and E14.5, because of severe intraembryonic hemorrhaging. They also display growth retardation and anemia. We investigated the expression of the beta-like globin genes in KLF2 knockout mice. Our results show that KLF2-/-mice have a significant reduction of murine embryonic Ey- and beta h1-globin but not zeta-globin gene expression in the E10.5 yolk sac, compared with wild-type mice. The expression of the adult beta(maj)- and beta(min)-globin genes is unaffected in the fetal livers of E12.5 embryos. In mice carrying the entire human globin locus, KLF2 also regulates the expression of the human embryonic epsilon-globin gene but not the adult beta-globin gene, suggesting that this developmental-stage-specific role is evolutionarily conserved. KLF2 also plays a role in the maturation and/or stability of erythroid cells in the yolk sac. KLF2-/-embryos have a significantly increased number of primitive erythroid cells undergoing apoptotic cell death."xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-02-0674"xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/author | "Basu P."xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/author | "Lingrel J.B."xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/author | "Wani M.A."xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/author | "Lloyd J.A."xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/author | "Gaensler K.M."xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/author | "Haar J.L."xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/author | "Morris P.E."xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/pages | "2566-2571"xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/title | "KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo."xsd:string |
| http://purl.uniprot.org/citations/15947087 | http://purl.uniprot.org/core/volume | "106"xsd:string |
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