| http://purl.uniprot.org/citations/15947484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15947484 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulatory role of signal transducer and activator of transcription (Stat) 5a in the proliferation and survival of mast cells was determined using Stat5a-deficient (Stat5a(-/-)) mice. First, although the mast cells in Stat5a(-/-) mice were morphologically indistinguishable from those in wild-type (WT) mice, the number of peritoneal mast cells was significantly decreased in Stat5a(-/-) mice as compared with that in WT mice. Furthermore, the interleukin-3 (IL-3)-dependent development of bone marrow-derived mast cells (BMMCs) was markedly decreased in Stat5a(-/-) mice. Second, IL-3-induced but not stem cell factor (SCF)-induced proliferation of BMMCs was significantly diminished in Stat5a(-/-) mice as compared with that in WT mice. Moreover, survival rates of both peritoneal mast cells and BMMCs were significantly decreased with increased apoptotic cells in Stat5a(-/-) mice as compared with those in WT mice. Finally, mRNA of Bcl-x(L) was induced after IL-3 stimulation in WT BMMCs but not in Stat5a(-/-) BMMCs, which may account for the accelerated apoptosis in Stat5a(-/-) mast cells. These results indicate that Stat5a plays an important role in mast cell development, proliferation, and survival."xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.org/dc/terms/identifier | "doi:10.1159/000085431"xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/author | "Ikeda K."xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/author | "Suzuki K."xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/author | "Nakajima H."xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/author | "Kagami S."xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/author | "Iwamoto I."xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/name | "Int Arch Allergy Immunol 137 Suppl"xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/pages | "45-50"xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/title | "Stat5a is essential for the proliferation and survival of murine mast cells."xsd:string |
| http://purl.uniprot.org/citations/15947484 | http://purl.uniprot.org/core/volume | "1"xsd:string |
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