| http://purl.uniprot.org/citations/15948139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15948139 | http://www.w3.org/2000/01/rdf-schema#comment | "Oligopeptidase B is a serine endopeptidase found in prokaryotes, unicellular eukaryotes and higher plants. The enzyme has been shown recently to play a central role in the pathogenesis of several parasitic diseases such as African trypanosomiasis, and to be a potential therapeutic target. This study reports that protamine, a basic peptide rich in arginine, is a potent inhibitor at the nanomolar level of oligopeptidase B from E. coli and wheat. Protamines 1B, 2C, 3A and TP17 displayed similar inhibitory activities and were capable of binding strongly to oligopeptidase B without proteolytic cleavage. The concentration of protamine needed for 50% inhibition (IC50) of oligopeptidase B was 10(4)-fold lower than the IC50 of trypsin. Oligopeptidase B was highly sensitive to inhibition by protamines even in the presence of serum (IC50, 1 microM). These data indicate that protamines might provide information useful for the design of more specific synthetic oligopeptidase B inhibitors."xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://purl.org/dc/terms/identifier | "doi:10.1002/psc.683"xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://purl.uniprot.org/core/author | "Matsuda Y."xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://purl.uniprot.org/core/author | "Yoshimoto T."xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://purl.uniprot.org/core/author | "Tsuji A."xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://purl.uniprot.org/core/author | "Yuasa K."xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/15948139 | http://purl.uniprot.org/core/name | "J Pept Sci"xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://purl.uniprot.org/core/pages | "65-71"xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://purl.uniprot.org/core/title | "Protamine: a unique and potent inhibitor of oligopeptidase B."xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/15948139 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15948139 |
| http://purl.uniprot.org/citations/15948139 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15948139 |
| http://purl.uniprot.org/uniprot/#_P24555-mappedCitation-15948139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15948139 |
| http://purl.uniprot.org/uniprot/P24555 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15948139 |