| http://purl.uniprot.org/citations/15948191 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15948191 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated whether endothelin-2/vasoactive intestinal contractor (ET-2/VIC) gene expression, upregulated by hypoxia in cancer cells, was associated with differentiation in neuronal cells. RT-PCR analysis, morphological observations, and immunostaining revealed that CoCl2, a hypoxic mimetic agent, at 200 microM increased expression of the ET-2/VIC gene, decreased expression of the ET-1 gene, and induced neurite outgrowth in PC-12 rat pheochromocytoma cells. These effects induced by 200 microM CoCl2 were completely inhibited by the antioxidant N-acetyl cysteine at 20 mM. In addition, CoCl2 increased the level of intracellular reactive oxygen species (ROS) at an early stage. Furthermore, interleukin (IL)-6 gene expression was upregulated upon the differentiation induced by CoCl2. These results suggest that expression of ET-2/VIC and ET-1 mediated by ROS may be associated with neuronal differentiation through the regulation of IL-6. When the cells were treated with 500 microM CoCl2 for 24 hr, however, ET-2/VIC gene expression disappeared, IL-6 gene expression was downregulated, and necrosis was subsequently induced in the PC-12 cells."xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.org/dc/terms/identifier | "doi:10.1002/jnr.20568"xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/author | "Quan J."xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/author | "Takizawa S."xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/author | "Saida K."xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/author | "Kotake-Nara E."xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/name | "J Neurosci Res"xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/pages | "563-571"xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/title | "Cobalt chloride induces neurite outgrowth in rat pheochromocytoma PC-12 cells through regulation of endothelin-2/vasoactive intestinal contractor."xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/15948191 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15948191 |
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