| http://purl.uniprot.org/citations/15949444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15949444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15949444 | http://www.w3.org/2000/01/rdf-schema#comment | "The periodic destruction of RAG-2 at the G1-to-S transition couples V(D)J recombination to the G0 and G1 cell cycle phases and coordinates RAG-mediated DNA cleavage with DNA repair by nonhomologous end joining. To define the mechanism by which this occurs, we reproduced cell cycle-dependent regulation of the V(D)J recombinase in a cell-free system. The ubiquitin-proteasomal pathway carries out destruction of RAG-2 in lysates of S phase cells and during S phase in vivo. Remarkably, the Skp2-SCF ubiquitin ligase, which plays a central role in cell cycle regulation through the destruction of p27, mediates ubiquitylation of RAG-2 in vitro and degradation of RAG-2 in vivo. The regulation of antigen receptor gene assembly by Skp2-SCF provides an unexpected and direct mechanistic link between DNA recombination and the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.05.011"xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.05.011"xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Jiang H."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Jiang H."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Nakayama K.'"xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Nakayama K.'"xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Desiderio S."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Desiderio S."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Ross A.E."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Ross A.E."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Chang F.C."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/author | "Chang F.C."xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/pages | "699-709"xsd:string |
| http://purl.uniprot.org/citations/15949444 | http://purl.uniprot.org/core/pages | "699-709"xsd:string |