| http://purl.uniprot.org/citations/15949633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15949633 | http://www.w3.org/2000/01/rdf-schema#comment | "Alpha-melanocyte stimulating hormone (alpha-MSH) has been identified as a potent anti-inflammatory peptide effective in various tissues including skin. It acts by inhibiting the production and action of several pro-inflammatory stimuli including TNF-alpha, IL-1beta and LPS in a number of cell types. The role of such stimuli in inducing cellular apoptosis is also well described; however the precise role of alpha-MSH in apoptosis is presently unclear, with studies reporting both anti- and pro-apoptotic activity. The present study demonstrates that cultured human dermal fibroblasts respond to serum depletion and TNF-alpha, IL-1beta and LPS with an increase in membrane permeability, a decrease in viability and an increase in phosphatidylserine externalization (indicative of apoptosis) over 48-96 h. alpha-MSH (at 10(-6) M, but not 10(-9) M) was found to inhibit the serum free and pro-inflammatory mediated reduction in membrane permeability and cellular viability and also inhibited increases in apoptosis. In conclusion, data support a cytoprotective and anti-apoptotic role of the alpha-MSH peptide in human dermal fibroblast cells."xsd:string |
| http://purl.uniprot.org/citations/15949633 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2005.01.019"xsd:string |
| http://purl.uniprot.org/citations/15949633 | http://purl.uniprot.org/core/author | "Wheeler P."xsd:string |
| http://purl.uniprot.org/citations/15949633 | http://purl.uniprot.org/core/author | "Haycock J.W."xsd:string |
| http://purl.uniprot.org/citations/15949633 | http://purl.uniprot.org/core/author | "Hill R.P."xsd:string |
| http://purl.uniprot.org/citations/15949633 | http://purl.uniprot.org/core/author | "MacNeil S."xsd:string |
| http://purl.uniprot.org/citations/15949633 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15949633 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/15949633 | http://purl.uniprot.org/core/pages | "1150-1158"xsd:string |
| http://purl.uniprot.org/citations/15949633 | http://purl.uniprot.org/core/title | "Alpha-melanocyte stimulating hormone cytoprotective biology in human dermal fibroblast cells."xsd:string |
| http://purl.uniprot.org/citations/15949633 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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