| http://purl.uniprot.org/citations/15949685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15949685 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied the influence of beta-carotene on the tobacco smoke carcinogen 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumor development in the A/J-mouse model. The normally low beta-carotene absorption was facilitated with a diet enriched in fat and bile salt, resulting in plasma and lung tissue levels similar to humans. beta-Carotene enhanced NNK-induced early bronchial cell proliferation, however, this effect was not predictive for later tumor development. Tumor multiplicity was not significantly affected by beta-carotene, neither in carcinogen-initiated nor in uninitiated mice, and regardless of dose and time point of supplementation during tumor development. RARbeta isoform and CYP26 gene expression levels analyzed by quantitative RT-PCR were weakly, but significantly, inversely correlated and showed evidence for altered retinoid signaling and catabolism in the lungs of NNK-initiated, beta-carotene supplemented mice. However, this interaction did not translate into enhanced tumor multiplicity. These results indicate that impaired retinoid signaling is not likely a key factor in lung tumorigenesis in this mouse model."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2005.01.005"xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/author | "Wertz K."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/author | "Bachmann H."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/author | "Riss G."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/author | "Lenz B."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/author | "Goralczyk R."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/author | "Aebischer C.P."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/author | "Buchwald Hunziker P."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/author | "Geatrix B."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/pages | "179-188"xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/title | "Beta-carotene interaction with NNK in the AJ-mouse model: effects on cell proliferation, tumor formation and retinoic acid responsive genes."xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://purl.uniprot.org/core/volume | "1740"xsd:string |
| http://purl.uniprot.org/citations/15949685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15949685 |
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