| http://purl.uniprot.org/citations/15950943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15950943 | http://www.w3.org/2000/01/rdf-schema#comment | "The Prnd-encoded prion protein (PrP)-like protein, Doppel (Dpl), is a homologue of Prnp-encoded PrP, and is N-glycosylated protein with glycosylphosphatidylinositol anchor like PrP. Recently, ectopic expressions of Prnp/Prnd chimeric mRNAs have been identified as the cause of late-onset ataxia observed in several lines of Prnp-knockout mice such as ZrchII, Ngsk, Rcm0, and Rikn mice. However, it remains unclear whether the toxic effect of Dpl expression is a cell-autonomous mechanism but rather reflect a systemic process of heterogeneous cell population in the brain. In this study, the cell-autonomous role of Dpl was estimated by investigating PrP-deficient cells (HpL3-4)-the SV40 large T-antigen immortalized and Rikn Prnp(-/-) mice-derived neuronal cell line expressing Prnp/Prnd chimeric mRNAs. The reverse transcription polymerase chain reaction revealed that serum deprivation did not increase Prnp/Prnd chimeric mRNAs, which in fact was translated into a small amount of Dpl in HpL3-4 cells, whereas serum deprivation induced apoptotic cell death of HpL3-4 cells. Dpl overexpression enhanced apoptotic cell death, whereas the toxic effect of Dpl on apoptotic cell death was neutralized by PrP expression. These results indicate that Dpl elicited dose-dependently toxic effects on PrP-deficient cells without affecting on PrP-expressing cells, suggesting that the PrP-Dpl interaction can regulate cell death in a cell-autonomous manner."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.05.128"xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/author | "Matsumoto Y."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/author | "Nakamura I."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/author | "Itohara S."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/author | "Saeki K."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/author | "Lee D.C."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/author | "Ikuta K."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/author | "Onodera T."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/author | "Taniuchi Y."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/author | "Sakudo A."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/pages | "448-454"xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/title | "Cell-autonomous PrP-Doppel interaction regulates apoptosis in PrP gene-deficient neuronal cells."xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://purl.uniprot.org/core/volume | "333"xsd:string |
| http://purl.uniprot.org/citations/15950943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15950943 |
| http://purl.uniprot.org/citations/15950943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15950943 |
| http://purl.uniprot.org/uniprot/#_A7U7N0-mappedCitation-15950943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15950943 |
| http://purl.uniprot.org/uniprot/#_C7E3P5-mappedCitation-15950943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15950943 |
| http://purl.uniprot.org/uniprot/#_Q3TZI7-mappedCitation-15950943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15950943 |
| http://purl.uniprot.org/uniprot/#_Q3UG89-mappedCitation-15950943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15950943 |
| http://purl.uniprot.org/uniprot/#_P04925-mappedCitation-15950943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15950943 |
| http://purl.uniprot.org/uniprot/#_Q3UBH0-mappedCitation-15950943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15950943 |