| http://purl.uniprot.org/citations/15953601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15953601 | http://www.w3.org/2000/01/rdf-schema#comment | "Red blood cell development is primarily controlled by erythropoietin (EPO). Several studies have revealed the importance of EPO-R Y343 and Y479 for erythroid cell growth, differentiation, and survival. In order to isolate critical signaling proteins that bind to EPO-R, we initiated a Cloning of Ligand Target (COLT) screen using a murine embryonic day 16 phage library and a biotinylated EPO-R Y343 phosphopeptide. One of the clones isolated encodes Phospholipase C (PLC)gamma1. PLCgamma1 is rapidly tyrosine phosphorylated upon EPO stimulation and associates with EPO-R in an SH2-domain-dependent manner. Although PLCgamma1 bound EPO-R Y343, Y401, Y429, Y431, and Y479 in the COLT screen, PLCgamma1 required Y479 for association with EPO-R in Ba/F3-EPO-R cells. Studies have identified EPO-R Y479 as important for ERK activation. Since PI3-kinase binds EPO-R Y479, one group has suggested that ERK activation downstream of PI3-kinase accounts for the importance of this residue in EPO signaling. However, we show that inhibition of PI3-kinase does not abolish ERK activation. Furthermore, we demonstrate interaction of PLCgamma1 with Grb2 and SOS2. Hence, we have identified a novel adapter function for PLCgamma1 in EPO signaling in which recruitment of PLCgamma1 to EPO-R may lead to activation of the ERK pathway."xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2005.04.030"xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/author | "Barber D.L."xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/author | "Chohan M."xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/author | "Beattie B.K."xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/author | "Miller B.A."xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/author | "Halupa A."xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/author | "Stickle N.H."xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/pages | "1-11"xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/title | "Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma."xsd:string |
| http://purl.uniprot.org/citations/15953601 | http://purl.uniprot.org/core/volume | "309"xsd:string |
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