| http://purl.uniprot.org/citations/15953655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15953655 | http://www.w3.org/2000/01/rdf-schema#comment | "There is growing evidence that folate metabolism is involved in migraine pathophysiology, mainly in migraine with aura. Even though folate metabolism is regulated by a number of enzymes, only two functional polymorphisms have been tested in association studies with migraine. Here, we have explored the possible role in migraine of other folate-metabolizing enzymes which are in close interdependency with 5',10'-methylenetetrahydrofolate reductase analyzing functional polymorphisms of these enzymes in a case-control study. Individually, thymidylate synthase (TS), methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthase (MTHFD1), or methionine synthase (MS) polymorphisms did not modify the general risk for suffering migraine. Nevertheless, we observed a strong interaction between TS and MTHFR mutated genotypes, which increased over 8-fold the risk for experiencing aura among migraineurs; MTHFD1 and MTHFR mutated genotypes also increased together the risk for migraine in general (OR = 3.08; 95% CI = 1.3-7.4). We conclude that the pathogenetic role of the MTHFR T677 allele in migraine is modulated by functional polymorphisms of TS and MTHFD1."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molbrainres.2005.05.015"xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Munoz P."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Pascual J."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Castillo J."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Oterino A."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Leyva-Cobian F."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Bravo Y."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Sanchez-Velasco P."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Ruiz-Alegria C."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Valle N."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/author | "Cid C."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/name | "Brain Res Mol Brain Res"xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/pages | "163-168"xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/title | "Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele."xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://purl.uniprot.org/core/volume | "139"xsd:string |
| http://purl.uniprot.org/citations/15953655 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15953655 |
| http://purl.uniprot.org/citations/15953655 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15953655 |
| http://purl.uniprot.org/uniprot/#_A0A1C9J7R9-mappedCitation-15953655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15953655 |
| http://purl.uniprot.org/uniprot/#_A0A1W5XGE6-mappedCitation-15953655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15953655 |
| http://purl.uniprot.org/uniprot/#_A0A482KFZ6-mappedCitation-15953655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15953655 |
| http://purl.uniprot.org/uniprot/#_A0A4P8L6T5-mappedCitation-15953655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15953655 |
| http://purl.uniprot.org/uniprot/#_A0A482KE01-mappedCitation-15953655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15953655 |