| http://purl.uniprot.org/citations/15955845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15955845 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular stimuli that activate cell surface receptors modulate glucocorticoid actions via as yet unclear mechanisms. Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gbeta interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. Association of Ggamma with Gbeta is necessary for this action of Gbeta. Both endogenous and enhanced green fluorescent protein (EGFP)-fused Gbeta2 and Ggamma2 proteins were detected in the nucleus at baseline, whereas a fraction of EGFP-Gbeta2 and DsRed2-GR comigrated to the nucleus or the plasma membrane, depending on the exposure of cells to dexamethasone or somatostatin, respectively. Gbeta2 was associated with GR/glucocorticoid response elements (GREs) in vivo and suppressed activation function-2-directed transcriptional activity of the GR. We conclude that the Gbetagamma complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters."xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200409150"xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/author | "Chrousos G.P."xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/author | "Tiulpakov A."xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/author | "Ichijo T."xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/author | "Kino T."xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/author | "Kozasa T."xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/author | "Chheng L."xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/pages | "885-896"xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/title | "G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/15955845 | http://purl.uniprot.org/core/volume | "169"xsd:string |
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