| http://purl.uniprot.org/citations/15961517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15961517 | http://www.w3.org/2000/01/rdf-schema#comment | "The fate of hematopoietic stem cells (HSCs) is regulated through a combinatorial action of proteins that determine their self-renewal and/or their commitment to differentiation. Stem cell leukemia/T-cell acute lymphoblastic leukemia 1 (SCL/TAL1), a basic helix-loop-helix (bHLH) transcription factor, plays key roles in controlling the development of primitive and definitive hematopoiesis during mouse development but its function in adult HSCs is still a matter of debate. We report here that the lentiviral-mediated enforced expression of TAL1 in human CD34+ cells marginally affects in vitro the differentiation of committed progenitors, whereas in vivo the repopulation capacity of the long-term SCID (severe combined immunodeficient) mouse-repopulating cells (LT-SRCs) is enhanced. As a consequence, the production of SRC-derived multipotent progenitors as well as erythroid- and myeloid-differentiated cells is increased. Looking at the lymphoid compartment, constitutive TAL1-enforced expression impairs B-but not T-cell differentiation. Expression of a mutant TAL1 protein that cannot bind DNA specifically impairs human LT-SRC amplification, indicating a DNA-binding dependent effect of TAL1 on primitive cell populations. These results indicate that TAL1 expression level regulates immature human hematopoietic cell self-renewal and that this regulation requires TAL1 DNA-binding activity."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-02-0557"xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/author | "Renia L."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/author | "Ravet E."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/author | "Romeo P.H."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/author | "Dubart-Kupperschmitt A."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/author | "Reynaud D."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/author | "Titeux M."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/author | "Pflumio F."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/author | "Mazurier F."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/pages | "2318-2328"xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/title | "SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment."xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/15961517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15961517 |
| http://purl.uniprot.org/citations/15961517 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15961517 |
| http://purl.uniprot.org/uniprot/#_Q16509-mappedCitation-15961517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15961517 |
| http://purl.uniprot.org/uniprot/#_P17542-mappedCitation-15961517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15961517 |
| http://purl.uniprot.org/uniprot/#_Q9NY94-mappedCitation-15961517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15961517 |
| http://purl.uniprot.org/uniprot/#_Q9UE36-mappedCitation-15961517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15961517 |
| http://purl.uniprot.org/uniprot/P17542 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15961517 |
| http://purl.uniprot.org/uniprot/Q9UE36 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15961517 |
| http://purl.uniprot.org/uniprot/Q16509 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15961517 |