| http://purl.uniprot.org/citations/15963783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15963783 | http://www.w3.org/2000/01/rdf-schema#comment | "The polymorphonuclear leukocyte (PMN)-derived serine proteases play a key role in immune complex (IC)-mediated inflammation. However, the mechanisms by which these proteases regulate inflammatory response remain largely undefined. Here, we show that IC-activated cathepsin G- and neutrophil elastase-deficient (CG/NE) PMNs adhered normally to IC-coated surfaces but did not undergo CD11b clustering and failed to initiate cytoskeletal reorganization and cell spreading. As a result, CG/NE-deficient PMNs exhibited severe defects in MIP-2 secretion and reactive oxygen intermediates production. Exogenously added CG, but not proteolytically inactive CG, was sufficient to restore these defects. These findings identify an important role for CG in integrin-dependent PMN effector functions that are separate from and downstream of integrin-dependent adhesion."xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2005.03.015"xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/author | "Pham C.T."xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/author | "Shapiro S.D."xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/author | "Cheng A.M."xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/author | "Raptis S.Z."xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/author | "Simmons P.M."xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/pages | "679-691"xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/title | "Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering."xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/15963783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15963783 |
| http://purl.uniprot.org/citations/15963783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15963783 |
| http://purl.uniprot.org/uniprot/#_P28293-mappedCitation-15963783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15963783 |
| http://purl.uniprot.org/uniprot/#_Q059V7-mappedCitation-15963783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15963783 |
| http://purl.uniprot.org/uniprot/#_Q3UP87-mappedCitation-15963783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15963783 |
| http://purl.uniprot.org/uniprot/P28293 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15963783 |
| http://purl.uniprot.org/uniprot/Q059V7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15963783 |
| http://purl.uniprot.org/uniprot/Q3UP87 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15963783 |