| http://purl.uniprot.org/citations/15964282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15964282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15964282 | http://www.w3.org/2000/01/rdf-schema#comment | "The impact of many microorganisms on their environment depends upon their ability to form surface bound communities called biofilms [1]. Biofilm formation on implanted medical devices has severe consequences for human health by providing both a portal of entry and a sanctuary for invasive bacterial and fungal pathogens [1 and 2]. Biofilm regulators and adherence molecules are extensively defined for many bacterial pathogens [3, 4, and 5], but not for fungal pathogens such as Candida albicans. Elongated filaments called hyphae are a prominent feature of C. albicans biofilms, and known genes that promote biofilm formation are required for hyphal development [2, 6, 7 and 8]. From a new library of transcription-factor mutants, we identify Bcr1p, a zinc finger protein required for formation of biofilms but not hyphae. Expression analysis shows that Bcr1p activates cell-surface protein and adhesin genes, including several induced during hyphal development. BCR1 expression depends upon the hyphal regulator Tec1p. Thus, BCR1 is a downstream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation. Our results indicate that hyphal cells are specialized to present adherence molecules that support biofilm integrity."xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2005.05.047"xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2005.05.047"xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/author | "Mitchell A.P."xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/author | "Mitchell A.P."xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/author | "Nobile C.J."xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/author | "Nobile C.J."xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/pages | "1150-1155"xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/pages | "1150-1155"xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/title | "Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p."xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/title | "Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p."xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15964282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15964282 |
| http://purl.uniprot.org/citations/15964282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15964282 |
| http://purl.uniprot.org/citations/15964282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15964282 |
| http://purl.uniprot.org/citations/15964282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15964282 |
| http://purl.uniprot.org/uniprot/Q5ANJ4 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15964282 |
| http://purl.uniprot.org/uniprot/P46593 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15964282 |