| http://purl.uniprot.org/citations/15967108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15967108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15967108 | http://www.w3.org/2000/01/rdf-schema#comment | "Chip profiling of a p53 temperature-sensitive tumor model identified SAK (Snk/Plk-akin kinase), encoding a new member of polo-like kinases (PLKs), as a gene strongly repressed by wild-type p53. Further characterization revealed that SAK expression was downregulated by wild-type p53 in several tumor cell models. Computer search of a 1.7-kb SAK promoter sequence revealed three putative p53 binding sites, but p53 failed to bind to any of these sites, indicating that SAK repression by p53 was not through a direct p53 binding to the promoter. Transcriptional analysis with luciferase reporters driven by SAK promoter deletion fragments identified SP-1 and CREB binding sites, which together conferred a two-fold SAK repression by p53. However, the repression was not reversed by cotransfection of SP-1 or CREB, suggesting a lack of interference between p53 and SP-1 or CREB. Significantly, p53-mediated SAK repression was largely reversed in a dose-dependent manner by Trichostatin A, a potent histone deacetylase (HDAC) inhibitor, suggesting an involvement of HDAC transcription repressors in SAK repression by p53. Biologically, SAK RNA interference (RNAi) silencing induced apoptosis, whereas SAK overexpression attenuated p53-induced apoptosis. Thus, SAK repression by p53 is likely mediated through the recruitment of HDAC repressors, and SAK repression contributes to p53-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.org/dc/terms/identifier | "doi:10.1593/neo.04325"xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.org/dc/terms/identifier | "doi:10.1593/neo.04325"xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Tan M."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Tan M."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Lawrence T.S."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Lawrence T.S."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Pamarthy D."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/author | "Pamarthy D."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/name | "Neoplasia"xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/name | "Neoplasia"xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/pages | "312-323"xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/pages | "312-323"xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/title | "SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing."xsd:string |
| http://purl.uniprot.org/citations/15967108 | http://purl.uniprot.org/core/title | "SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing."xsd:string |