| http://purl.uniprot.org/citations/15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15967825 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD1d reactive glycolipid, alpha-galactosylceramide (alpha-GalCer), potently activates T cell receptor-alpha type I invariant NKT cells that secondarily stimulate the proliferation and activation of other leukocytes, including NK cells. Here we report a rational approach to improving the antitumor activity of alpha-GalCer by using delayed interleukin (IL)-21 treatment to mature the alpha-GalCer-expanded pool of NK cells into highly cytotoxic effector cells. In a series of experimental and spontaneous metastases models in mice, we demonstrate far superior antitumor activity of the alpha-GalCer/IL-21 combination above either agent alone. Superior antitumor activity was critically dependent upon the increased perforin-mediated cytolytic activity of NK cells. Transfer of alpha-GalCer-pulsed dendritic cells (DCs) followed by systemic IL-21 caused an even more significant reduction in established (day 8) metastatic burden and prolonged survival. In addition, this combination prevented chemical carcinogenesis more effectively. Combinations of IL-21 with other NK cell-activating cytokines, such as IL-2 and IL-12, were much less effective in the same experimental metastases models, and these cytokines did not substitute effectively for IL-21 in combination with alpha-GalCer. Overall, the data suggest that NK cell antitumor function can be enhanced greatly by strategies that are designed to expand and differentiate NK cells via DC activation of NKT cells."xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20042280"xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/author | "Godfrey D.I."xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/author | "Hayakawa Y."xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/author | "Nutt S.L."xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/author | "Wallace M.E."xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/pages | "1973-1985"xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/title | "Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer."xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://purl.uniprot.org/core/volume | "201"xsd:string |
| http://purl.uniprot.org/citations/15967825 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15967825 |
| http://purl.uniprot.org/citations/15967825 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15967825 |
| http://purl.uniprot.org/uniprot/#_A0A0U5CJG6-mappedCitation-15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15967825 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STF5-mappedCitation-15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15967825 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15967825 |
| http://purl.uniprot.org/uniprot/#_A1Y9B0-mappedCitation-15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15967825 |
| http://purl.uniprot.org/uniprot/#_A2RSY7-mappedCitation-15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15967825 |
| http://purl.uniprot.org/uniprot/#_A0PJ18-mappedCitation-15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15967825 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15967825 |
| http://purl.uniprot.org/uniprot/#_P70380-mappedCitation-15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15967825 |
| http://purl.uniprot.org/uniprot/#_G3UY25-mappedCitation-15967825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15967825 |