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| http://purl.uniprot.org/citations/15967991 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of extracellular signal-regulated kinase (Erk) 1/2, which plays a critical role in diverse cellular processes, including cell proliferation, is known to be mediated by the canonical Raf-mitogen-activated protein kinase kinase (MEK) kinase cascade. Alternative MEK-independent signaling pathways for Erk1/2 activation in mammalian cells are not known. During our studies of human primary Schwann cell response to long-term infection of Mycobacterium leprae, the causative organism of leprosy, we identified that intracellular M. leprae activated Erk1/2 directly by lymphoid cell kinase (p56Lck), a Src family member, by means of a PKCepsilon-dependent and MEK-independent signaling pathway. Activation of this signaling induced nuclear accumulation of cyclin D1, G1/S-phase progression, and continuous proliferation, but without transformation. Thus, our data reveal a previously unknown signaling mechanism of glial cell proliferation, which might play a role in dedifferentiation as well as nerve regeneration and degeneration. Our findings may also provide a potential mechanism by which an obligate intracellular bacterial pathogen like M. leprae subverts nervous system signaling to propagate its cellular niche for colonization and long-term bacterial survival."xsd:string |
| http://purl.uniprot.org/citations/15967991 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0501196102"xsd:string |
| http://purl.uniprot.org/citations/15967991 | http://purl.uniprot.org/core/author | "Rambukkana A."xsd:string |
| http://purl.uniprot.org/citations/15967991 | http://purl.uniprot.org/core/author | "Tapinos N."xsd:string |
| http://purl.uniprot.org/citations/15967991 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15967991 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/15967991 | http://purl.uniprot.org/core/pages | "9188-9193"xsd:string |
| http://purl.uniprot.org/citations/15967991 | http://purl.uniprot.org/core/title | "Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli."xsd:string |
| http://purl.uniprot.org/citations/15967991 | http://purl.uniprot.org/core/volume | "102"xsd:string |
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