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http://purl.uniprot.org/citations/15969672http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15969672http://www.w3.org/2000/01/rdf-schema#comment"

Background

The significance of specific T cell receptor (TCR) Vbeta subtypes and human leucocyte antigen (HLA) class II alleles for the development of allergy to lipocalin allergens such as the major dog allergen Can f 1 is not clear at present.

Objective

To characterize the TCR Vbeta usage in the Can f 1-specific T cell lines and the HLA class II genotypes of Can f 1-allergic and non-allergic subjects.

Methods

T cell lines were induced with recombinant Can f 1 from the peripheral blood mononuclear cells of 12 non-atopic dog owners and 26 dog-allergic patients. Thirteen of the dog-allergic subjects were sensitized to Can f 1. Expression of the TCR Vbeta subtypes on CD4(+) T cells in the T cell lines was measured by flow cytometry. The subjects were HLA genotyped for DRB1, DQB1 and DPB1 loci.

Results

Can f 1-specific T cell lines were obtained from 18 subjects, with either positive (n=8) or negative (n=10) skin prick tests (SPTs) to recombinant Can f 1. The frequency of TCR Vbeta5.1(+) T cells was significantly higher in the T cell lines of subjects with negative SPTs to the allergen. Moreover, DR4-DQ8 haplotype was over-represented among these subjects.

Conclusion

The DR4-DQ8 haplotype and the TCR Vbeta5.1(+) CD4(+) T cells may be protective against allergy to Can f 1."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-2222.2005.02247.x"xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/author"Taivainen A."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/author"Partanen J."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/author"Rautiainen J."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/author"Virtanen T."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/author"Kinnunen T."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/author"Rytkonen-Nissinen M."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/author"Immonen A."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/author"Saarelainen S."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/name"Clin Exp Allergy"xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/pages"797-803"xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/title"The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1."xsd:string
http://purl.uniprot.org/citations/15969672http://purl.uniprot.org/core/volume"35"xsd:string
http://purl.uniprot.org/citations/15969672http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15969672
http://purl.uniprot.org/citations/15969672http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15969672
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http://purl.uniprot.org/uniprot/#_A0A0A7C545-mappedCitation-15969672http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15969672
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