| http://purl.uniprot.org/citations/15975902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15975902 | http://www.w3.org/2000/01/rdf-schema#comment | "Relatively little is known about how microtubule motors are controlled or about how the functions of different cytoskeletal systems are integrated. A yeast two-hybrid screen for proteins that bind to Drosophila Enabled (Ena), an actin polymerization factor that is negatively regulated by Abl tyrosine kinase, identified kinesin heavy chain (Khc), a member of the kinesin-1 subfamily of microtubule motors. Coimmunoprecipitation from Drosophila cytosol confirmed a physical interaction between Khc and Ena. Kinesin-1 motors can carry organelles and other macromolecular cargoes from neuronal cell bodies toward terminals in fast-axonal-transport. Ena distribution in larval axons was not affected by mutations in the Khc gene, suggesting that Ena is not itself a fast transport cargo of Drosophila kinesin-1. Genetic interaction tests showed that in a background sensitized by reduced Khc gene dosage, a reduction in Abl gene dosage caused distal paralysis and axonal swellings. A concomitant reduction in ena dosage rescued those defects. These results suggest that Ena/VASP, when not inhibited by the Abl pathway, can bind Khc and reduce its transport activity in axons."xsd:string |
| http://purl.uniprot.org/citations/15975902 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-02-0116"xsd:string |
| http://purl.uniprot.org/citations/15975902 | http://purl.uniprot.org/core/author | "Martin M."xsd:string |
| http://purl.uniprot.org/citations/15975902 | http://purl.uniprot.org/core/author | "Hoffmann F.M."xsd:string |
| http://purl.uniprot.org/citations/15975902 | http://purl.uniprot.org/core/author | "Saxton W.M."xsd:string |
| http://purl.uniprot.org/citations/15975902 | http://purl.uniprot.org/core/author | "Ahern-Djamali S.M."xsd:string |
| http://purl.uniprot.org/citations/15975902 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15975902 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/15975902 | http://purl.uniprot.org/core/pages | "4225-4230"xsd:string |
| http://purl.uniprot.org/citations/15975902 | http://purl.uniprot.org/core/title | "Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1."xsd:string |
| http://purl.uniprot.org/citations/15975902 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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