| http://purl.uniprot.org/citations/15978049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15978049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15978049 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER). In this case, so-called unfolded protein response (UPR) genes are induced. We determined the transcriptional expression of Arabidopsis thaliana UPR genes by fluid microarray analysis of tunicamycin-treated plantlets. Two hundred and fifteen up-regulated genes and 17 down-regulated ones were identified. These genes were reanalyzed with functional DNA microarrays, using DNA fragments cloned through fluid microarray analysis. Finally, 36 up-regulated and two down-regulated genes were recognized as UPR genes. Among them, the up-regulation of genes related to protein degradation (HRD1, SEL-1L/HRD3 and DER1), regulation of translation (P58(IPK)), and apoptosis (BAX inhibitor-1) was reconfirmed by real-time reverse transcriptase-PCR. The induction of SEL-1L protein in an Arabidopsis membrane fraction on tunicamycin-treatment was demonstrated. Phosphorylation of initiation factor-2alpha, which was inhibited by P58(IPK), was decreased in tunicamycin-treated plantlets. However, regulatory changes in translation caused by ER stress were not detected in Arabidopsis. Plant cells appeared to have a strategy for overcoming ER stress through enhancement of protein folding activity, degradation of unfolded proteins, and regulation of apoptosis, but not regulation of translation."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1742-4658.2005.04770.x"xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1742-4658.2005.04770.x"xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/author | "Nakatani H."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/author | "Nakatani H."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/author | "Nakano C."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/author | "Nakano C."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/author | "Kamauchi S."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/author | "Kamauchi S."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/author | "Urade R."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/author | "Urade R."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/name | "FEBS J."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/name | "FEBS J."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/pages | "3461-3476"xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/pages | "3461-3476"xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/title | "Gene expression in response to endoplasmic reticulum stress in Arabidopsis thaliana."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/title | "Gene expression in response to endoplasmic reticulum stress in Arabidopsis thaliana."xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/15978049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15978049 |
| http://purl.uniprot.org/citations/15978049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15978049 |