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http://purl.uniprot.org/citations/15979955http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15979955http://www.w3.org/2000/01/rdf-schema#comment"

Background

Coeliac disease is associated with DQ2 and DQ8 alleles, but other genes also confer an additional genetic risk.

Aims

Defining whether the genetic profiles of interleukin-10, tumour necrosis factor alpha and interferon gamma are associated with an increased coeliac disease risk.

Patients and methods

The functionally gene polymorphisms of tumour necrosis factor alpha (-308G/A), interferon gamma (+874T/A) and interleukin-10 (-1082G/A) were typed using sequence specific primer-polymerase chain reaction in 110 Sicilian coeliac disease patients and in 220 Sicilian healthy controls.

Results

No differences in genotype frequencies of interleukin-10 polymorphisms were found between coeliac disease patients and healthy controls. A significant increase of -308A (p<0.033; OR: 1.72; CI: 1.27-2.33) and of +874T (p: 0.0045; OR: 3.02; CI: 1.47-6.21) allele frequencies, both in hetero- and homozygosis, was observed in coeliac patients in comparison with healthy controls. In addition, simultaneous significant higher percentages of -308A and +874T alleles (p: 0.0066; OR: 2.33; CI: 1.42-3.82) as well as simultaneous significant lower percentages of -308A and +874T alleles (p: 0.003; OR: 0.23; CI: 0.10-0.60) were observed in coeliac patients compared with healthy controls.

Conclusions

Genetically determined higher frequencies of -308A tumour necrosis factor alpha and +874T interferon gamma alleles, both in hetero and in homozygosis and mostly whether simultaneous, may play a role in predisposing to gluten intolerance. Subjects positive for -308A tumour necrosis factor alpha and +874T interferon gamma alleles have an increased risk for coeliac disease."xsd:string
http://purl.uniprot.org/citations/15979955http://purl.org/dc/terms/identifier"doi:10.1016/j.dld.2005.04.027"xsd:string
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/author"Forte G.I."xsd:string
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/author"Lio D."xsd:string
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/author"Scola L."xsd:string
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/author"Crivello A."xsd:string
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http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/author"Accomando S."xsd:string
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/author"Giacalone A."xsd:string
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/name"Dig Liver Dis"xsd:string
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/pages"756-760"xsd:string
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/title"TNFalpha, IFNgamma and IL-10 gene polymorphisms in a sample of Sicilian patients with coeliac disease."xsd:string
http://purl.uniprot.org/citations/15979955http://purl.uniprot.org/core/volume"37"xsd:string
http://purl.uniprot.org/citations/15979955http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15979955
http://purl.uniprot.org/citations/15979955http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15979955
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