http://purl.uniprot.org/citations/15980434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15980434 | http://www.w3.org/2000/01/rdf-schema#comment | "The Kruppel-like factor KLF2 was recently identified as a novel regulator of endothelial pro-inflammatory and pro-thrombotic function. Here it is shown that overexpression of KLF2 potently inhibits vascular permeability factor/vascular endothelial growth factor (VEGF-A)-mediated angiogenesis and tissue edema in the nude ear mouse model of angiogenesis. In vitro, KLF2 expression retards VEGF-mediated calcium flux, proliferation and induction of pro-inflammatory factors in endothelial cells. This effect is due to a potent inhibition of VEGFR2/KDR expression and promoter activity. These observations identify KLF2 as a regulator of VEGFR2/KDR and provide a foundation for novel approaches to regulate angiogenesis."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c500200200"xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/author | "Lin Z."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/author | "Mukhopadhyay D."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/author | "Mir S."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/author | "Mukherjee P."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/author | "Jain M.K."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/author | "Bhattacharya R."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/author | "Hamik A."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/author | "Senbanerjee S."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/pages | "28848-28851"xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/title | "Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2."xsd:string |
http://purl.uniprot.org/citations/15980434 | http://purl.uniprot.org/core/volume | "280"xsd:string |
http://purl.uniprot.org/citations/15980434 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15980434 |
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