| http://purl.uniprot.org/citations/15983387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15983387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15983387 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the identification and characterization of a potent regulator of genomic integrity, mouse and human FRAG1 gene, a conserved homolog of replication factor C large subunit that is homologous to the alternative replication factor C subunits Elg1, Ctf18/Chl12, and Rad24 of budding yeast. FRAG1 was identified in a search for key caretaker genes involved in the regulation of genomic stability under conditions of replicative stress. In response to stress, Atr participates in the down-regulation of FRAG1 expression, leading to the induction of apoptosis through the release of Rad9 from damaged chromatin during the S phase of the cell cycle, allowing Rad9-Bcl2 association and induction of proapoptotic Bax protein. We propose that the Frag1 signal pathway, by linking replication stress surveillance with apoptosis induction, plays a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0504222102"xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0504222102"xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Ozawa K."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Ozawa K."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Huebner K."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Huebner K."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Furukawa Y."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Furukawa Y."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Sasaki H."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Sasaki H."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Isobe M."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Isobe M."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Inageta T."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Inageta T."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Ishii H."xsd:string |
| http://purl.uniprot.org/citations/15983387 | http://purl.uniprot.org/core/author | "Ishii H."xsd:string |