| http://purl.uniprot.org/citations/15983867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15983867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15983867 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear receptor superfamily expanded in at least two episodes: one early in metazoan evolution, the second within the vertebrate lineage. An exception to this pattern is the genome of the nematode Caenorhabditis elegans, which encodes more than 270 nuclear receptors, most of them highly divergent. We generated 128 cDNA sequences for 76 C. elegans nuclear receptors, confirming that these are active genes. Among these numerous receptors are 13 orthologues of nuclear receptors found in arthropods and/or vertebrates. We show that the supplementary nuclear receptors (supnrs) originated from an explosive burst of duplications of a unique orphan receptor, HNF4. This origin has specific implications for the role of ligand binding in the function and evolution of the nematode supplementary nuclear receptors. Moreover, the supplementary nuclear receptors include a group of very rapidly evolving genes found primarily on chromosome V. We propose a model of lineage-specific duplications from a chromosome on which duplication and substitution rates are highly increased. Our results provide a framework to study nuclear receptors in nematodes, as well as to consider the functional and evolutionary consequences of lineage-specific duplications."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00239-004-0175-8"xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00239-004-0175-8"xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Laudet V."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Laudet V."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Robinson-Rechavi M."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Robinson-Rechavi M."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Maina C.V."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Maina C.V."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Gissendanner C.R."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Gissendanner C.R."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Sluder A."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/author | "Sluder A."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/name | "J. Mol. Evol."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/name | "J. Mol. Evol."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/pages | "577-586"xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/pages | "577-586"xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/title | "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/title | "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes."xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/15983867 | http://purl.uniprot.org/core/volume | "60"xsd:string |