| http://purl.uniprot.org/citations/15988025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15988025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15988025 | http://www.w3.org/2000/01/rdf-schema#comment | "Genome replication in eukaryotic cells necessitates the stringent coupling of histone biosynthesis with the onset of DNA replication at the G1/S phase transition. A fundamental question is the mechanism that links the restriction (R) point late in G1 with histone gene expression at the onset of S phase. Here we demonstrate that HiNF-P, a transcriptional regulator of replication-dependent histone H4 genes, interacts directly with p220(NPAT), a substrate of cyclin E/CDK2, to coactivate histone genes during S phase. HiNF-P and p220 are targeted to, and colocalize at, subnuclear foci (Cajal bodies) in a cell cycle-dependent manner. Genetic or biochemical disruption of the HiNF-P/p220 interaction compromises histone H4 gene activation at the G1/S phase transition and impedes cell cycle progression. Our results show that HiNF-P and p220 form a critical regulatory module that directly links histone H4 gene expression at the G1/S phase transition to the cyclin E/CDK2 signaling pathway at the R point."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.14.6140-6153.2005"xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.14.6140-6153.2005"xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Mitra P."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Mitra P."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Stein G.S."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Stein G.S."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Stein J.L."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Stein J.L."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "van Wijnen A.J."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "van Wijnen A.J."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Ye X."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Ye X."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Miele A."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Miele A."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Medina R."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Medina R."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Braastad C.D."xsd:string |
| http://purl.uniprot.org/citations/15988025 | http://purl.uniprot.org/core/author | "Braastad C.D."xsd:string |