| http://purl.uniprot.org/citations/15989966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15989966 | http://www.w3.org/2000/01/rdf-schema#comment | "Growth-dependent regulation of rRNA synthesis is mediated by TIF-IA, a basal transcription initiation factor for RNA polymerase I. We inactivated the murine TIF-IA gene by homologous recombination in mice and embryonic fibroblasts (MEFs). TIF-IA-/-embryos die before or at embryonic day 9.5 (E9.5), displaying retardation of growth and development. In MEFs, Cre-mediated depletion of TIF-IA leads to disruption of nucleoli, cell cycle arrest, upregulation of p53, and induction of apoptosis. Elevated levels of p53 after TIF-IA depletion are due to increased binding of ribosomal proteins, such as L11, to MDM2 and decreased interaction of MDM2 with p53 and p19(ARF). RNAi-induced loss of p53 overcomes proliferation arrest and apoptosis in response to TIF-IA ablation. The striking correlation between perturbation of nucleolar function, elevated levels of p53, and induction of cell suicide supports the view that the nucleolus is a stress sensor that regulates p53 activity."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.05.023"xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/author | "Yuan X."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/author | "Kiss E."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/author | "Grone H.J."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/author | "Casanova E."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/author | "Chai M."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/author | "Grummt I."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/author | "Schutz G."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/pages | "77-87"xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/title | "Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/15989966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15989966 |
| http://purl.uniprot.org/citations/15989966 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15989966 |
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| http://purl.uniprot.org/uniprot/B2RS91#attribution-2CD23155282DB2E358B27E6EDE67E888 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15989966 |
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| http://purl.uniprot.org/uniprot/#_D3YYT0-mappedCitation-15989966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15989966 |