| http://purl.uniprot.org/citations/15990875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15990875 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) inhibits osteoblast differentiation through inhibition of the function of Runx2 (Cbfa1) by Smad3. The mechanism through which TGF-beta/Smad3 inhibits Runx2 function has not been characterized. We show that TGF-beta induces histone deacetylation, primarily of histone H4, at the osteocalcin promoter, which is repressed by TGF-beta, and that histone deacetylation is required for repression of Runx2 by TGF-beta. This repression occurs through the action of the class IIa histone deacetylases (HDAC)4 and 5, which are recruited through interaction with Smad3 to the Smad3/Runx2 complex at the Runx2-binding DNA sequence. Accordingly, HDAC4 or 5 is required for efficient TGF-beta-mediated inhibition of Runx2 function and is involved in osteoblast differentiation. Our results indicate that class IIa HDACs act as corepressors for TGF-beta/Smad3-mediated transcriptional repression of Runx2 function in differentiating osteoblasts and are cell-intrinsic regulators of osteoblast differentiation."xsd:string |
| http://purl.uniprot.org/citations/15990875 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600729"xsd:string |
| http://purl.uniprot.org/citations/15990875 | http://purl.uniprot.org/core/author | "Derynck R."xsd:string |
| http://purl.uniprot.org/citations/15990875 | http://purl.uniprot.org/core/author | "Kang J.S."xsd:string |
| http://purl.uniprot.org/citations/15990875 | http://purl.uniprot.org/core/author | "Delston R."xsd:string |
| http://purl.uniprot.org/citations/15990875 | http://purl.uniprot.org/core/author | "Alliston T."xsd:string |
| http://purl.uniprot.org/citations/15990875 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15990875 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/15990875 | http://purl.uniprot.org/core/pages | "2543-2555"xsd:string |
| http://purl.uniprot.org/citations/15990875 | http://purl.uniprot.org/core/title | "Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3."xsd:string |
| http://purl.uniprot.org/citations/15990875 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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