| http://purl.uniprot.org/citations/15992539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15992539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15992539 | http://www.w3.org/2000/01/rdf-schema#comment | "Stretch induces lung embryonic mesenchymal cells to follow a myogenic pathway. Using this system we identified a set of stretch-responsive factors, which we referred to as TIPs (tension-induced/inhibited proteins). TIPs displayed signature motifs characteristic of nuclear receptor coregulators and chromatin remodeling enzymes. A genomic BLAST search suggested that the three TIPs identified were isoforms originated by alternative splicing from a single gene. Functional studies revealed that TIP-1 and TIP-3 were involved in the cell's selection of the myogenic or the adipogenic pathway. TIP-1, induced by stretch, promoted myogenesis, while TIP-3, inhibited by stretch, stimulated adipogenesis. The selection involved TIP-mediated chromatin remodeling via a histone acetylation process and depended on TIP-1 and TIP-3 nuclear receptor binding boxes (NRBs). This study, therefore, suggests a new developmental mechanism linking the presence or absence of tension with divergent differentiation pathways."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2005.04.015"xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2005.04.015"xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Pan D."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Pan D."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Schuger L."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Schuger L."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Choudhury R."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Choudhury R."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Jakkaraju S."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Jakkaraju S."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Zhe X."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/author | "Zhe X."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/pages | "39-49"xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/pages | "39-49"xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/title | "TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/title | "TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation."xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/15992539 | http://purl.uniprot.org/core/volume | "9"xsd:string |